WebARID1A-mutated cancers 3. Targeting residual SWI/SNF complex as a specific vulnerability in ARID1A-mutated cancers 4. Targeting mutual exclusivity ... encoding the ATPase SWI/SNF subunit BRG1, in non-small cell lung cancer increase sensitivity to a combinatorial EZH2 and topoisomerase inhibition [6]. WebApr 9, 2024 · Context.—. Somatic mutations in SMARCA4 (SWI/SNF–related, matrix-associated, actin-dependent regulator of chromatin, subfamily A, member 4) gene and/or BRG1 (Brahma-related gene 1) loss identifies a subset of non–small cell lung carcinomas (NSCLCs) lacking alterations in EGFR (epidermal growth factor receptor), ALK …
Exquisite Sensitivity to Dual BRG1/BRM ATPase …
WebDec 13, 2024 · Data suggest there are over 30 different cancers with brahma-related gene-1 (BRG1) mutations accounting for approximately 5% of all tumors with up to 10% of non-small cell lung cancer tumors,... WebApr 12, 2024 · In addition to these studies, forthcoming press releases will feature groundbreaking research on perioperative immunotherapy for operable lung cancer (Abstract CT005), a novel allogeneic chimeric ... coles glebe hill tas
MD Anderson Research Highlights: AACR 2024 Special Edition
WebApr 4, 2024 · Brahma-related gene 1 (BRG1) function in cancer is context dependent. BRG1 is mutated in lung and other cancers, where it may function as a tumor suppressor (30, 47). Cancers that have lost the SWI/SNF INI1 subunit require BRG1 , suggesting that targeting BRG1 may be therapeutic for these tumors. WebAug 15, 2024 · Development of novel, selective SMARCA2 (BRM) degraders for treatment of SMARCA4 (BRG1) mutated tumors [abstract]. In: Proceedings of the Annual Meeting of the American Association for Cancer Research 2024; 2024 Apr 27-28 and Jun 22-24. Philadelphia (PA): AACR; Cancer Res 2024;80 (16 Suppl):Abstract nr 3656. WebSMARCA4 (BRG1) and SMARCA2 (BRM) are two crucial components of the SWI/SNF complex that share about 75% identity at the protein level. While SMARCA4 is the most frequently mutated chromatin remodeling ATPase in cancer, the SMARCA2 protein and other SWI/SNF subunits are thought to act as tumor suppressors. coles gift card participating stores