Web19 de mar. de 2024 · Generation of mice with temporal overexpression of HIF-2 in intestinal epithelial cells (Vil-ERT2Hif2 LSL/LSL). To exam-ine the effects of temporal activation of HIF-2 on intestinal homeostasis, we generated Vil-ERT2Hif2 LSL/LSL mice by crossing Vil-ERT2 mice with Hif2 LSL/LSL that harbor an oxygen-stable HIF-2 flanked … WebNational Center for Biotechnology Information

A novel HIF-2α targeted inhibitor suppresses hypoxia-induced …

Web暨南大学,数字图书馆. 开馆时间：周一至周日7:00-22:30 周五 7:00-12:00; 我的图书馆 Web11 de out. de 2024 · ARG2 is a target of the hypoxia inducible factors (HIF1−α and HIF2−α), and is required for the generation of polyamines which are required for cell growth. ... ARG2 is variably expressed in leukemic cells and is regulated by HIF1-α and HIF2-α. Overexpression of ARG2 has been reported in solid tumours [27 ... how big is medium pizza

National Center for Biotechnology Information

WebBenzene is an environmental contaminant which causes hematological diseases. Previously, hypoxia inducible factor-1a (HIF-1a) was found to be involved in benzene … Webwe demonstrated that HIF2 α could promote migration and invasion in gastric cancer cells. The results of western blot and RT-PCR analysis indicated that Survivin, Cyclin D1, MMP2 and MMP9 are upregulated with HIF2α overexpression. Finally, similar roles of HIF2 α also in vivo were demonstrated. Web21 de jul. de 2010 · The oxygen-sensitive hypoxia inducible factor (HIF) transcriptional regulators HIF-1α and HIF-2α are overexpressed in many human NSCLCs, and constitutive HIF-2α activity can promote murine lung tumor progression, suggesting that HIF proteins may be effective NSCLC therapeutic targets. To investigate the consequences of … how many oscars has ryan reynolds won