Webb16 okt. 2024 · Serine/threonine kinase 4 (STK4) deficiency is an autosomal recessive genetic condition that leads to primary immunodeficiency (PID) typically characterized by lymphopenia, recurrent infections and Epstein Barr Virus (EBV) induced lymphoproliferation and -lymphoma. WebbThe phenotype of human STK4 deficiency. Blood. 2012; 119: 3450-3457. Crossref; PubMed; Scopus (32) Google Scholar; MST1-deficient patients demonstrated hypergammaglobulinemia and variable humoral responses. However, B-cell numbers (especially memory B-cell numbers) were significantly reduced in one report. 19. …
Genetic susceptibility to EBV infection: insights from inborn errors …
Webb16 rader · 12 apr. 2012 · STK4 is the human ortholog of Drosophila Hippo, the central constituent of a highly conserved ... Webb16 okt. 2024 · Introduction. Deficiency of serine/threonine kinase 4 (STK4), also referred to as mammalian sterile 20-like protein (MST1), is an autosomal recessive primary immunodeficiency (PID) typically characterized by profound CD4 lymphopenia and recurring infections (1–6).STK4 deficiency in humans leads to decreased proliferation, … buying car tyres
(PDF) The phenotype of human STK4 deficiency
Webb9 mars 2024 · Epstein–Barr virus (EBV) is a ubiquitous human pathogen, infecting > 90% of the adult population. In the vast majority of healthy individuals, infection with EBV runs a relatively benign course. However, EBV is by no means a benign pathogen. Indeed, apart from being associated with at least seven different types of malignancies, EBV infection … Webb31 jan. 2012 · STK4 is the human ortholog of Drosophila Hippo, the central constituent of a highly conserved pathway controlling cell growth and apoptosis. STK4-deficient … Webb12 okt. 2012 · STK4 deficiency results in a primary T-cell immunodeficiency syndrome characterized by progressive loss of naive T cells, recurrent bacterial, viral, and fungal infections, warts, and abscesses, autoimmune manifestations, and cardiac malformations, including atrial septal defect ( Abdollahpour et al., 2012; Nehme et al., 2012 ). Clinical … centerpoint energy human resources number